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CYP Inhibition Assay Analysis
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Home / Contract Research / in vitro ADME Screening / CYP Inhibition ...
RapidFire® CYP Inhibition Analysis Service
Your Analysis Done in 3 Days.
The RapidFire CYP Inhibition Analysis Service provides high quality mass spectrometry based CYP inhibition assay data using FDA recommended drug probes and liver microsomes generating data that correlates with conventional LC-MS techniques. Efficiently assessing CYP inhibition allows early detection of possible deleterious competitive drug interactions by potential lead compounds. Several leading pharmaceutical companies have published CYP inhibition data using the RapidFire System.
The RapidFire CYP Inhibition Analysis Service integrates easily into existing laboratory workflows. Laborious sample preparation is not required – simply send us quenched 96 or 384 well plates from the defined CYP assays containing labeled internal standard. Samples are analyzed using BIOCIUS RapidFire microscale solid-phase extraction sample preparation system interfaced to a triple-quadrupole mass spectrometer.
BIOCIUS can analyze CYP inhibition assays (competitive or time dependent) for a number of P450 isoforms. Results are delivered with very fast turnaround times in a format that is easy to interpret and analyze.
| Available CYP Assays | |
| CYP1A2 | (tacrine, melatonin) |
| CYP2B6 | (bupropion) |
| CYP2C8 | (amodiaquin, taxol) |
| CYP2C9 | (tolbutamide, diclofenac) |
| CYP2C19 | (S-mephenytoin, omeprazole) |
| CYP2D6 | (dextromethorphan, bufuralol) |
| CYP2E1 | (chlorzoxazone) |
| CYP3A4/5 | (midazolam, nifedipine, erythromycin, testosterone) |
| Custom assay development available. | |
BIOCIUS’s experienced scientists have screened millions of wells for our clients in the pharmaceutical and biotechnology industries in support of their drug discovery efforts. RapidFire Contract Research Services enable researchers to:
- increase efficiency of laboratory resources
- obtain more data faster without compromising assay integrity
- make better informed decisions
BIOCIUS. Faster Answers.
RapidFire® technology is described in patent numbers 6,932,939, 6,812,030 7,100,460, 7,588,725,